Lipid-dependence of Kv7 Activator Drugs: Insights for Selective & Effective Potassium Channel Therapeutics
- Defining how Kv7 activators modulate voltage-gated potassium channels to improve mechanistic understanding of ion channel pharmacology
- Revealing how membrane lipid composition influences drug activity, specificity, and channel regulation across Kv7 subtypes
- Applying molecular-level insights to understand selectivity, potency, and efficacy of potassium channel targeted therapeutics for epilepsy and pain disorders