Reducing Translational Risk by Interpreting Ion Channel Pharmacology in Human Nociceptors

• Revealing how ion channel behavior in human nociceptors differs from animal models and recombinant systems used in early discovery
• Interpreting state dependent and activity dependent pharmacology to avoid false confidence from simplified assay readouts
• Improving early development decisions by aligning electrophysiology data with native human neuronal function

Speakers:

Bruce Bean

Professor of Neurobiology

Harvard Medical School