Selective Sodium Channel Blockade to Deliver Clinical Efficacy in Refractory Chronic Cough
- Selective local targeting of cough nociceptors to provide meaningful clinical outcomes in patients with refractory chronic cough
- Interpreting Phase 2b clinical data to understand exposure response relationships, tolerability & efficacy
- Achieving sufficient local exposure in lung tissue while avoiding systemic liability
- Human proof of concept for selective sodium channel blockade to de-risk respiratory ion channel development