Structuring Early Ion Channel Drug Discovery for Panx1 to Enable Structure-Guided Hit Identification & Validation
- Leveraging Salipro® membrane protein stabilisation to enable high-resolution structural access to Panx1 for drug discovery
- Integrating DEL screening, electrophysiology, and cryo-EM structure validation into a unified early hit identification workflow
- Demonstrating a full structure-enabled discovery package from stabilised membrane protein to validated small-molecule hits in an emerging CNS, pain, and oncologyrelevant target space