Alexei Pushechnikov
Vice President MedChem Mair Therapeutics
Seminars
Wednesday 23rd September 2026
Panel: Comparing Modality Selection Decisions to Match Biology & Indication Requirements
4:30 pm
- Examining how biology, delivery constraints & safety risk shaped final modality choices
- Weighing durability, tissue access, reversibility & tolerability across competing strategies
- Identifying modality decision principles that remain consistent across CNS & peripheral programs
Wednesday 23rd September 2026
Advancing Lysosomal Ion Channel Programs from Early Discovery into Confident Lead Optimization
11:45 am
- Clarifying target rationale for lysosomal ion channels implicated in neurodegenerative disease to support early investment decisions
- Integrating electrophysiology, functional cell assays & chemistry iteration to progress intracellular channel hits toward development candidates
- Managing assay design & mechanistic uncertainty when optimizing compounds against non‑plasma membrane ion channels
- Achieving high brain penetrance while maintaining potency
