Rajesh Khanna
Chief Scientific Officer Regulonix
Rajesh Khanna is Professor and Director of the Center for Advanced Pain Therapeutics and Research (CAPToR) at the University of Florida and Chief Scientific Officer of Regulonix, where he leads the development of non-opioid therapeutics targeting ion channel regulation for chronic pain. His research focuses on the allosteric regulation and trafficking of voltage-gated ion channels, including NaV1.7 and CaV2.2, to develop safer, non-addictive analgesics. Rajesh has held leadership roles at NYU, the University of Arizona, and Indiana University, and has authored numerous translational studies spanning electrophysiology, molecular pharmacology, and pain neurobiology.
Seminars
Wednesday 23rd September 2026
Redirecting NaV1.7 Trafficking to Deliver Selective Pain Relief Without CNS Liabilities
2:00 pm
- Targeting the CRMP2–SUMOylation pathway to indirectly regulate NaV1.7 surface expression and DRG excitability
- Demonstrating a differentiated strategy to overcome the clinical limitations of direct NaV1.7 pore blockers
- Advancing small molecules against the CRMP2–SUMO interface toward first-in-human development through NIH collaboration
