Stefan McDonough
Adjunct Professor of Brain Science Brown University
Seminars
Wednesday 23rd September 2026
Using Nucleic Acid & Gene-Based Strategies to Achieve Subtype- Selective Ion Channel Modulation
1:15 pm
- Designing subtype-selective ion channel modulation beyond conventional small molecule targeting approaches
- Addressing key challenges in oligonucleotide delivery, tissue distribution, and neuronal uptake to enable effective modulation of excitability pathways
- Exploring where nucleic acid-based approaches offer the greatest advantage in pain and broader excitability disorders
Wednesday 23rd September 2026
Panel: Comparing Modality Selection Decisions to Match Biology & Indication Requirements
4:30 pm
- Examining how biology, delivery constraints & safety risk shaped final modality choices
- Weighing durability, tissue access, reversibility & tolerability across competing strategies
- Identifying modality decision principles that remain consistent across CNS & peripheral programs
