Using Nucleic Acid & Gene-Based Strategies to Achieve Subtype- Selective Ion Channel Modulation

  • Designing subtype-selective ion channel modulation beyond conventional small molecule targeting approaches
  • Addressing key challenges in oligonucleotide delivery, tissue distribution, and neuronal uptake to enable effective modulation of excitability pathways
  • Exploring where nucleic acid-based approaches offer the greatest advantage in pain and broader excitability disorders